Oxiglutatione
Navstel (oxiglutatione) is a small molecule pharmaceutical. Oxiglutatione was first approved as Navstel on 2008-07-24. The pharmaceutical is active against glutathione reductase, mitochondrial.
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FDA approval date
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Study first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Combinations
Bss (discontinued: Methotrexate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcium chloride
+
Dextrose
+
Glutathione disulfide
+
Magnesium chloride
+
Potassium chloride
+
Sodium bicarbonate
+
Sodium chloride
+
Sodium phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BSS PLUS | Alcon Research | N-018469 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | 1 | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Liver failure | D017093 | HP_0001399 | K72.9 | — | 1 | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | — | 1 | — | — | — | 1 |
| Reperfusion injury | D015427 | — | — | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
| Preleukemia | D011289 | — | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Oxiglutatione |
| INN | oxiglutatione |
| Description | Glutathione disulfide (GSSG) is a disulfide derived from two glutathione molecules.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 27025-41-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1372 |
| ChEBI ID | 17858 |
| PubChem CID | 11215652 |
| DrugBank | DB03310 |
| UNII ID | ULW86O013H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GSTM2
GSTM2
Organism
Homo sapiens
Gene name
GSTM2
Gene synonyms
GST4
NCBI Gene ID
Protein name
glutathione S-transferase Mu 2
Protein synonyms
epididymis secretory sperm binding protein, glutathione S-alkyltransferase M2, glutathione S-aralkyltransferase M2, glutathione S-aryltransferase M2, glutathione S-transferase 4, glutathione S-transferase M1, glutathione S-transferase M2 (muscle), glutathione S-transferase mu 2 (muscle), GST class-mu 2, GST, muscle, GSTM2-2, S-(hydroxyalkyl)glutathione lyase M2
Uniprot ID
Mouse ortholog
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—
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11,365 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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238 adverse events reported
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